POLYETHYLENE GLYCOL–POLYLACTIC ACID NANOPARTICLES MODIFIED WITH CYSTEINE–ARGININE–GLUTAMIC ACID–LYSINE–ALANINE FIBRIN-HOMING PEPTIDE FOR GLIOBLASTOMA THERAPY BY ENHANCED RETENTION EFFECT

Junzhu Wu,1,2,* Jingjing Zhao,1,3,* Bo Zhang,1 Yong Qian,1 Huile Gao,1 Yuan Yu,1 Yan Wei,1 Zhi Yang,1 Xinguo Jiang,1 Zhiqing Pang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 2School of Pharmacy, Dali University, Xiaguan, 3School of Pharmacy, China Pharm

Following ischemic stroke astrocytes undergo rapid molecular and functional changes that may accentuate tissue damage.In this study we identified the neurotrophin receptor TrkB in astrocytes as a key promoter of acute CNS injury in ischemic stroke.In fact, TrkB protein was strongly upregulated in astrocytes after human and experimental stroke, and

Summary: DLX transcription factors (TFs) are master regulators of the developing vertebrate brain, driving forebrain GABAergic neuronal differentiation.Ablation of Dlx1&2 alters expression of genes that are critical for forebrain GABAergic development.We integrated epigenomic and transcriptomic analyses, complemented with in situ hybridization (ISH

Abstract Background Unprofessional behaviours of healthcare staff have negative impacts on organisational outcomes, patient safety and staff well-being.The objective of this study was to undertake a qualitative analysis of narrative responses from the Longitudinal Investigation of Cropped Trousers Negative Behaviours survey (LION), to develop a com